CATH Classification

Domain Context

CATH Clusters

Superfamily 2.60.200.20
Functional Family bifunctional polynucleotide phosphatase/kinase

Enzyme Information

2.7.1.78
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt Q9JLV6
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
3.1.3.32
Polynucleotide 3'-phosphatase.
based on mapping to UniProt Q9JLV6
A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.

UniProtKB Entries (1)

Q9JLV6
PNKP_MOUSE
Mus musculus
Bifunctional polynucleotide phosphatase/kinase

PDB Structure

PDB 1YJM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase.
Bernstein, N.K., Williams, R.S., Rakovszky, M.L., Cui, D., Green, R., Karimi-Busheri, F., Mani, R.S., Galicia, S., Koch, C.A., Cass, C.E., Durocher, D., Weinfeld, M., Glover, J.N.
Mol.Cell