CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Serine/threonine-protein kinase pim-1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P11309
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P11309
PIM1_HUMAN
Homo sapiens
Serine/threonine-protein kinase pim-1

PDB Structure

PDB 1YI4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Jacobs, M.D., Black, J., Futer, O., Swenson, L., Hare, B., Fleming, M., Saxena, K.
J.Biol.Chem.