CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P0A6G7
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P0A6G7
CLPP_ECOLI
Escherichia coli K-12
ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB 1YG8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The asymmetry in the mature amino-terminus of ClpP facilitates a local symmetry match in ClpAP and ClpXP complexes.
Bewley, M.C., Graziano, V., Griffin, K., Flanagan, J.M.
J.Struct.Biol.