CATH Classification

Domain Context

CATH Clusters

Superfamily S-ribosylhomocysteinase (LuxS)
Functional Family

Enzyme Information

4.4.1.21
S-ribosylhomocysteine lyase.
based on mapping to UniProt O34667
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5- dihydroxypentan-2,3-dione.
-!- The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density. -!- Formerly EC 3.2.1.148 and EC 3.3.1.3.

UniProtKB Entries (1)

O34667
LUXS_BACSU
Bacillus subtilis subsp. subtilis str. 168
S-ribosylhomocysteine lyase

PDB Structure

PDB 1YCL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of S-Ribosylhomocysteinase (LuxS) in Complex with a Catalytic 2-Ketone Intermediate.
Rajan, R., Zhu, J., Hu, X., Pei, D., Bell, C.E.
Biochemistry