CATH Classification

Domain Context

CATH Clusters

Superfamily alpha/beta hydrolase
Functional Family Carboxylic ester hydrolase

Enzyme Information

3.1.1.56
Methylumbelliferyl-acetate deacetylase.
based on mapping to UniProt P23141
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
-!- Acts on short-chain acyl esters of 4-methylumbelliferone, but not on naphthyl, indoxyl or thiocholine esters.
3.1.1.1
Carboxylesterase.
based on mapping to UniProt P23141
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
-!- Wide specificity; also hydrolyzes vitamin A esters. -!- The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4 and EC 3.5.1.13. -!- Formerly EC 3.1.1.12.

UniProtKB Entries (1)

P23141
EST1_HUMAN
Homo sapiens
Liver carboxylesterase 1

PDB Structure

PDB 1YAJ
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil.
Fleming, C.D., Bencharit, S., Edwards, C.C., Hyatt, J.L., Tsurkan, L., Bai, F., Fraga, C., Morton, C.L., Howard-Williams, E.L., Potter, P.M., Redinbo, M.R.
J.Mol.Biol.