CATH Classification

Domain Context

CATH Clusters

Superfamily Heme oxygenase-like
Functional Family

Enzyme Information

3.5.99.2
Aminopyrimidine aminohydrolase.
based on mapping to UniProt P25052
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
-!- Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.

UniProtKB Entries (1)

P25052
TENA_BACSU
Bacillus subtilis subsp. subtilis str. 168
Aminopyrimidine aminohydrolase

PDB Structure

PDB 1YAF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II.
Toms, A.V., Haas, A.L., Park, J.H., Begley, T.P., Ealick, S.E.
Biochemistry