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1 keywords

CATH Domain 1xxeA02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1700 lpxc deacetylase, domain 1
Homologous Superfamily 3.30.1700.10 lpxc deacetylase, domain 2

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 2
Functional Family

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt O67648
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

O67648
LPXC_AQUAE
Aquifex aeolicus VF5
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 1XXE
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Refined Solution Structure of the LpxC-TU-514 Complex and pK(a) Analysis of an Active Site Histidine: Insights into the Mechanism and Inhibitor Design
Coggins, B.E., McClerren, A.L., Jiang, L., Li, X., Rudolph, J., Hindsgaul, O., Raetz, C.R.H., Zhou, P.
Biochemistry
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