CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1280.30
Functional Family Methane monooxygenase, hydrolase gamma chain

Enzyme Information

1.14.13.25
Methane monooxygenase (soluble).
based on mapping to UniProt P11987
Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O.
-!- The enzyme is soluble, in contrast to the particulate enzyme, EC 1.14.18.3. -!- Broad specificity; many alkanes can be hydroxylated, and alkenes are converted into the corresponding epoxides; CO is oxidized to CO(2), ammonia is oxidized to hydroxylamine, and some aromatic compounds and cyclic alkanes can also be hydroxylated, but more slowly.

UniProtKB Entries (1)

P22869
MEMA_METCA
Methylococcus capsulatus str. Bath
Methane monooxygenase component A alpha chain

PDB Structure

PDB 1XVE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Product Bound Structures of the Soluble Methane Monooxygenase Hydroxylase from Methylococcus capsulatus (Bath): Protein Motion in the Alpha-Subunit
Sazinsky, M.H., Lippard, S.J.
J.Am.Chem.Soc.