CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family Nudix hydrolase 2

Enzyme Information

3.6.1.17
Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical).
based on mapping to UniProt P50583
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H(2)O = GTP + GMP.
-!- Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate (cf. EC 3.6.1.41).

UniProtKB Entries (1)

P50583
AP4A_HUMAN
Homo sapiens
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

PDB Structure

PDB 1XSA
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Structure and Substrate-binding Mechanism of Human Ap4A Hydrolase
Swarbrick, J.D., Buyya, S., Gunawardana, D., Gayler, K.R., McLennan, A.G., Gooley, P.R.
J.Biol.Chem.