CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.280 | Cobalamin-binding domain |
Domain Context
CATH Clusters
| Superfamily | Cobalamin-binding domain |
| Functional Family |
Enzyme Information
| 5.4.3.3 |
Lysine 5,6-aminomutase.
based on mapping to UniProt E3PRJ4
(1) (3S)-3,6-diaminohexanoate = (3S,5S)-3,5-diaminohexanoate. (2) D-lysine = 2,5-diaminohexanoate.
-!- This enzyme is a member of the 'AdoMet radical' (radical SAM) family. -!- A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of adenosylcobalamin, which is regenerated at the end of the reaction. -!- Formerly EC 5.4.3.4.
|
UniProtKB Entries (1)
| E3PRJ4 |
KAME_ACESD
Acetoanaerobium sticklandii DSM 519
Lysine 5,6-aminomutase beta subunit
|
PDB Structure
| PDB | 1XRS |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase.
Proc.Natl.Acad.Sci.Usa
|
