CATH Domain 1xrpA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family

Enzyme Information

3.4.11.5

Prolyl aminopeptidase.

based on mapping to UniProt P96084

Release of N-terminal proline from a peptide.

-!- Present in the cytosol of mammalian and microbial cells. -!- In contrast to the mammalian form, the bacterial form of the enzyme hydrolyzes both polyproline and prolyl-2-naphthylamide. -!- The mammalian enzyme, which is not specific for prolyl bonds, is possibly identical with EC 3.4.11.1. -!- Belongs to peptidase family S33. -!- Formerly EC 3.4.1.4.

UniProtKB Entries (1)

P96084

PIP_THEAC

Thermoplasma acidophilum DSM 1728

Proline iminopeptidase

PDB Structure

PDB	1XRP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	X-ray snapshots of peptide processing in mutants of tricorn-interacting factor F1 from Thermoplasma acidophilum Goettig, P., Brandstetter, H., Groll, M., Goehring, W., Konarev, P.V., Svergun, D.I., Huber, R., Kim, J.-S. J.Biol.Chem.