1 keywords

CATH Domain 1xqhA01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.20 Single Sheet
Topology 2.20.110 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Homologous Superfamily 2.20.110.10 Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain

Domain Context

CATH Clusters

Superfamily Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
Functional Family Histone-lysine N-methyltransferase SETD7

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q8WTS6
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q8WTS6
SETD7_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SETD7

PDB Structure

PDB 1XQH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Regulation of p53 activity through lysine methylation
Chuikov, S., Kurash, J.K., Wilson, J.R., Xiao, B., Justin, N., Ivanov, G.S., McKinney, K., Tempst, P., Prives, C., Gamblin, S.J., Barlev, N.A., Reinberg, D.
Nature