CATH Classification

Domain Context

CATH Clusters

Superfamily RNA polymerase, RBP11-like subunit
Functional Family

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt Q9HIC5
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

Q9HIC5
RPOL_THEAC
Thermoplasma acidophilum DSM 1728
DNA-directed RNA polymerase subunit L

PDB Structure

PDB 1XPP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of TA1416, DNA-directed RNA polymerase subunit L, from Thermoplasma acidophilum
Kim, Y., Joachimiak, A., Evdokimova, E., Savchenko, A., Edwards, A.
To be Published