CATH Classification

Domain Context

CATH Clusters

Superfamily Crotonobetainyl-coa:carnitine coa-transferase; domain 1
Functional Family

Enzyme Information

2.8.3.21
L-carnitine CoA-transferase.
based on mapping to UniProt P31572
(1) (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4- (trimethylammonio)but-2-enoate + L-carnitinyl-CoA. (2) 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.
-!- The enzyme is found in gammaproteobacteria such as Proteus sp. and Escherichia coli. -!- It has similar activity with both substrates. -!- Formerly EC 4.2.1.89.

UniProtKB Entries (1)

P31572
CAIB_ECOLI
Escherichia coli K-12
L-carnitine CoA-transferase

PDB Structure

PDB 1XK6
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Escherichia coli Crotonobetainyl-CoA: Carnitine CoA-Transferase (CaiB) and Its Complexes with CoA and Carnitinyl-CoA.
Rangarajan, E.S., Li, Y., Iannuzzi, P., Cygler, M., Matte, A.
Biochemistry