CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family probable leucine aminopeptidase 2

Enzyme Information

3.4.11.24
Aminopeptidase S.
based on mapping to UniProt P80561
Release of an N-terminal amino acid with a preference for large hydrophobic amino-terminus residues.
-!- Activated by Ca(2+). -!- In the presence of Ca(2+), the best substrates are Leu-Phe, Leu-Ser, Leu-pNA (aminoacyl-p-nitroanilide), Phe-Phe-Phe and Phe-Phe. -!- Peptides with proline in the P1' position are not substrates. -!- Belongs to peptidase family M28. -!- Formerly EC 3.4.11.n1.

UniProtKB Entries (1)

P80561
APX_STRGG
Streptomyces griseus subsp. griseus NBRC 13350
Aminopeptidase S

PDB Structure

PDB 1XJO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 A resolution.
Greenblatt, H.M., Almog, O., Maras, B., Spungin-Bialik, A., Barra, D., Blumberg, S., Shoham, G.
J.Mol.Biol.