CATH Classification

Domain Context

CATH Clusters

Superfamily Spermidine synthase, tetramerisation domain
Functional Family Spermidine synthase 1

Enzyme Information

2.5.1.16
Spermidine synthase.
based on mapping to UniProt Q9ZUB3
S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl- 5'-thioadenosine + spermidine.
-!- The enzymes from the plant Glycine max and from mammalia are highly specific for putrescine as the amine acceptor. -!- The enzymes from the bacteria Escherichia coli and Thermotoga maritima prefer putrescine but are more tolerant toward other amine acceptors, such as spermidine and cadaverine. -!- Cf. EC 2.5.1.22 and EC 2.5.1.23.

UniProtKB Entries (1)

Q9ZUB3
SPD1_ARATH
Arabidopsis thaliana
Spermidine synthase 1

PDB Structure

PDB 1XJ5
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-RAY STRUCTURE OF SPERMIDINE SYNTHASE FROM ARABIDOPSIS THALIANA GENE AT1G23820
Center for Eukaryotic Structural Genomics
To be published