CATH Classification

Domain Context

CATH Clusters

Superfamily Anthrax toxin, edema factor, central domain
Functional Family

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P40136
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (2)

P40136
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase
P0DP25
CALM3_HUMAN
Homo sapiens
Calmodulin-3

PDB Structure

PDB 1XFW
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
EMBO J.