CATH Classification

Domain Context

CATH Clusters

Superfamily Subtilisin-like superfamily
Functional Family

Enzyme Information

3.4.21.110
C5a peptidase.
based on mapping to UniProt P15926
The primary cleavage site is at 67-His-|-Lys-68 in human C5a with a minor secondary cleavage site at 58-Ala-|-Ser-59.
-!- Surface-associated subtilisin-like serine peptidase with very specific substrate specificity. -!- Virulent strains of streptococci, including Streptococcus pyogenes, can evade human detection and phagocytosis by destroying the complement chemotaxin C5a. -!- Cleavage of human C5a by this enzyme reduces the ability of C5a to bind receptors on the surface of polymorphonuclear neutrophil leukocytes (PMNLs) and thereby abolishes its chemotactic properties. -!- Belongs to peptidase family S8A.

UniProtKB Entries (1)

P15926
C5AP_STRPY
Streptococcus pyogenes
C5a peptidase

PDB Structure

PDB 1XF1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the streptococcal cell wall C5a peptidase
Brown, C.K., Gu, Z.Y., Matsuka, Y.V., Purushothaman, S.S., Winter, L.A., Cleary, P.P., Olmsted, S.B., Ohlendorf, D.H., Earhart, C.A.
Proc.Natl.Acad.Sci.Usa