CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Plasmepsin-2

Enzyme Information

3.4.23.39
Plasmepsin II.
based on mapping to UniProt P46925
Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.
-!- Inhibited by pepstatin. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P46925
PLM2_PLAFA
Plasmodium falciparum
Plasmepsin-2

PDB Structure

PDB 1XE5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of plasmepsin II in complex of an pepstatin analogue
Prade, L.
To be published