CATH Domain 1xe4A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.30	Gcn5-related N-acetyltransferase (GNAT)

Domain Context

CATH Clusters

Superfamily	3.40.630.30
Functional Family

Enzyme Information

2.3.2.10

UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase.

based on mapping to UniProt Q9EY50

L-alanyl-tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L- lysyl-D-alanyl-D-alanine = tRNA(Ala) + UDP-N-acetyl-alpha-D-muramoyl-L- alanyl-D-glutamyl-N(6)-(L-alanyl)-L-lysyl-D-alanyl-D-alanine.

-!- Also acts on L-seryl-tRNA(Ser).

UniProtKB Entries (1)

Q9EY50

FEMX_WEIVI

Weissella viridescens

UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase

PDB Structure

PDB	1XE4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structure-Based Site-Directed Mutagenesis of the UDP-MurNAc-Pentapeptide-Binding Cavity of the FemX Alanyl Transferase from Weissella viridescens Maillard, A.P., Biarrotte-Sorin, S., Villet, R., Mesnage, S., Bouhss, A., Sougakoff, W., Mayer, C., Arthur, M. J.Bacteriol.