CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.1280 | Alpha/beta knot |
|
3.40.1280.10 | SPOUT methyltransferase, trefoil knot domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.1280.10 |
| Functional Family |
Enzyme Information
| 2.1.1.208 |
23S rRNA (uridine(2479)-2'-O)-methyltransferase.
based on mapping to UniProt Q9F5K6
S-adenosyl-L-methionine + uridine(2479) in 23S rRNA = S-adenosyl-L- homocysteine + 2'-O-methyluridine(2479) in 23S rRNA.
-!- Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis. -!- To protect itself from the antibiotic, Streptomyces viridochromogenes utilizes two methyltransferases, 23S rRNA (uridine(2479)-2'-O)- methyltransferase and EC 2.1.1.209 whose actions confer avilamycin resistance to the RNA.
|
UniProtKB Entries (1)
| Q9F5K6 |
AVRB_STRVR
Streptomyces viridochromogenes
23S rRNA (uridine(2479)-2'-O)-methyltransferase
|
PDB Structure
| PDB | 1X7O |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes
J.Mol.Biol.
|
