CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Coagulation factor X

Enzyme Information

3.4.21.22
Coagulation factor IXa.
based on mapping to UniProt P16293
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- The proenzyme factor IX is activated by EC 3.4.21.27. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P16293
FA9_PIG
Sus scrofa
Coagulation factor IX

PDB Structure

PDB 1X7A
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa
Smallheer, J.M., Alexander, R.S., Wang, J., Wang, S., Nakajima, S., Rossi, K.A., Smallwood, A., Barbera, F., Burdick, D., Luettgen, J.M., Knabb, R.M., Wexler, R.R., Jadhav, P.K.
Bioorg.Med.Chem.Lett.