CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein kinase Lck

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (2)

Q63767
BCAR1_RAT
Rattus norvegicus
Breast cancer anti-estrogen resistance protein 1
P06239
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

PDB 1X27
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Molecular basis for regulation of Src by the docking protein p130Cas
Nasertorabi, F., Tars, K., Becherer, K., Kodandapani, R., Liljas, L., Vuori, K., Ely, K.R.
J.MOL.RECOG.