CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family NAD(P) transhydrogenase subunit alpha

Enzyme Information

7.1.1.1
Proton-translocating NAD(P)(+) transhydrogenase.
based on mapping to UniProt P07001
NADPH + NAD(+) + H(+)(Side 1) = NADP(+) + H(+)(Side 2) + NADH.
-!- The enzyme is a membrane bound proton-translocating pyridine nucleotide transhydrogenase that couples the reversible reduction of NADP by NADH to an inward proton translocation across the membrane. -!- In the bacterium Escherichia coli the enzyme provides a major source of cytosolic NADPH. -!- Detoxification of reactive oxygen species in mitochondria by glutathione peroxidases depends on NADPH produced by this enzyme. -!- Formerly EC 1.6.1.5.

UniProtKB Entries (1)

P07001
PNTA_ECOLI
Escherichia coli K-12
NAD(P) transhydrogenase subunit alpha

PDB Structure

PDB 1X14
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
X-ray Structure of Domain I of the Proton-pumping Membrane Protein Transhydrogenase from Escherichia coli
Johansson, T., Oswald, C., Pedersen, A., Tornroth, S., Okvist, M., Karlsson, B.G., Rydstrom, J., Krengel, U.
J.Mol.Biol.