CATH Classification

Domain Context

CATH Clusters

Superfamily Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

1.4.4.2
Glycine dehydrogenase (aminomethyl-transferring).
based on mapping to UniProt Q5SKW7
Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L- lysine + CO(2).
-!- A component of the glycine cleavage system, which is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein. -!- Previously known as glycine synthase.

UniProtKB Entries (1)

Q5SKW8
Q5SKW8_THET8
Thermus thermophilus HB8
Probable glycine dehydrogenase (decarboxylating) subunit 1

PDB Structure

PDB 1WYU
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia
Nakai, T., Nakagawa, N., Maoka, N., Masui, R., Kuramitsu, S., Kamiya, N.
Embo J.