CATH Domain 1wuqA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1130	GTP Cyclohydrolase I, domain 2
	3.30.1130.10	GTP cyclohydrolase I, C-terminal domain/NADPH-dependent 7-cyano-7-deazaguanine reductase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	3.30.1130.10
Functional Family	GTP cyclohydrolase 1

Enzyme Information

UniProtKB Entries (1)

Q5SH52_THET8

Thermus thermophilus HB8

GTP cyclohydrolase 1

PDB Structure

PDB	1WUQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative Tanaka, Y., Nakagawa, N., Kuramitsu, S., Yokoyama, S., Masui, R. J.Biochem.(Tokyo)