CATH Classification

Domain Context

CATH Clusters

Superfamily Aminomethyltransferase fragment
Functional Family Aminomethyltransferase

Enzyme Information

2.1.2.10
Aminomethyltransferase.
based on mapping to UniProt P48728
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.

UniProtKB Entries (1)

P48728
GCST_HUMAN
Homo sapiens
Aminomethyltransferase, mitochondrial

PDB Structure

PDB 1WSV
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0A Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia
Okamura-Ikeda, K., Hosaka, H., Yoshimura, M., Yamashita, E., Toma, S., Nakagawa, A., Fujiwara, K., Motokawa, Y., Taniguchi, H.
J.Mol.Biol.