CATH Classification

Domain Context

CATH Clusters

Superfamily Poly(ADP-ribose) polymerase, regulatory domain
Functional Family Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-
Pentosyltransferases.
based on mapping to UniProt P09874
2.4.2.30
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt P09874
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

P09874
PARP1_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase 1

PDB Structure

PDB 1WOK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors.
Iwashita, A., Hattori, K., Yamamoto, H., Ishida, J., Kido, Y., Kamijo, K., Murano, K., Miyake, H., Kinoshita, T., Warizaya, M., Ohkubo, M., Matsuoka, N., Mutoh, S.
Febs Lett.