CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46881
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.
1.4.3.-
With oxygen as acceptor.
based on mapping to UniProt P46881

UniProtKB Entries (1)

P46881
PAOX_ARTGO
Arthrobacter globiformis
Phenylethylamine oxidase

PDB Structure

PDB 1WMN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Reinvestigation of metal ion specificity for quinone cofactor biogenesis in bacterial copper amine oxidase
Okajima, T., Kishishita, S., Chiu, Y.C., Murakawa, T., Kim, M., Yamaguchi, H., Hirota, S., Kuroda, S., Tanizawa, K.
Biochemistry