CATH Classification

Domain Context

CATH Clusters

Superfamily Putative methyltransferase TM0872, insert domain
Functional Family

Enzyme Information

2.1.1.199
16S rRNA (cytosine(1402)-N(4))-methyltransferase.
based on mapping to UniProt Q5SJD8
S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L- homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.
-!- RsmH catalyzes the N(4)-methylation of cytosine(1402) and RsmI (EC 2.1.1.198) catalyzes the 2'-O-methylation of cytosine(1402) in 16S rRNA. -!- Both methylations are necessary for efficient translation initiation at the UUG and GUG codons.

UniProtKB Entries (1)

Q5SJD8
RSMH_THET8
Thermus thermophilus HB8
Ribosomal RNA small subunit methyltransferase H

PDB Structure

PDB 1WG8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of a predicted S-adenosylmethionine-dependent methyltransferase TT1512 from Thermus thermophilus HB8 at 2.0 Ang. resolution.
Kishishita, S., Murayama, K., Shirouzu, M., Yokoyama, S.
To be Published