CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.1360.140
Functional Family DNA-directed RNA polymerase subunit

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt P04050
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P34087
RPB7_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB7

PDB Structure

PDB 1WCM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of Complete RNA Polymerase II and its Subcomplex,Rpb4/7
Armache, K.-J., Mitterweger, S., Meinhart, A., Cramer, P.
J.Biol.Chem.