CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Pyruvate dehydrogenase E1 beta subunit

Enzyme Information

1.2.4.1
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P21874
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

UniProtKB Entries (1)

P21873
ODPA_GEOSE
Geobacillus stearothermophilus
Pyruvate dehydrogenase E1 component subunit alpha

PDB Structure

PDB 1W88
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
A Molecular Switch and Proton-Wire Synchronize the Active Sites in Thiamine-Dependent Enzymes
Frank, R.A.W., Titman, C.M., Pratap, J.V., Luisi, B.F., Perham, R.N.
Science