CATH Classification

Domain Context

CATH Clusters

Superfamily Laminin
Functional Family Coagulation factor VII

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 1W7X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Selective and Orally Bioavailable Phenylglycine Tissue Factor/Factor Viia Inhibitors.
Zbinden, K.G., Obst-Sander, U., Hilpert, K., Kuhne, H., Banner, D.W., Bohm, H.J., Stahl, M., Ackermann, J., Alig, L., Weber, L., Wessel, H.P., Riederer, M.A., Tschopp, T.B., Lave, T.
Bioorg.Med.Chem.Lett.