CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46881
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881
PAOX_ARTGO
Arthrobacter globiformis
Phenylethylamine oxidase

PDB Structure

PDB 1W4N
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Complexes of the Copper-Containing Amine Oxidase from Arthrobacter Globiformis with the Inhibitors Benzylhydrazine and Tranylcypromine.
Langley, D.B., Trambaiolo, D.M., Duff, A.P., Dooley, D.M., Freeman, H.C., Guss, J.M.
Acta Crystallogr.,Sect.F