CATH Classification

Domain Context

CATH Clusters

Superfamily Chondroitin AC/alginate lyase
Functional Family

Enzyme Information

4.2.2.1
Hyaluronate lyase.
based on mapping to UniProt Q54873
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.

UniProtKB Entries (1)

Q54873
HYSA_STRPN
Streptococcus pneumoniae TIGR4
Hyaluronate lyase

PDB Structure

PDB 1W3Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
L-Ascorbic Acid 6-Hexadecanoate, a Potent Hyaluronidase Inhibitor: X-Ray Structure and Molecular Modeling of Enzyme-Inhibitor Complexes
Botzki, A., Rigden, D.J., Braun, S., Nukui, M., Salmen, S., Hoechstetter, J., Bernhardt, G., Dove, S., Jedrzejas, M.J., Buschauer, A.
J.Biol.Chem.