CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt Q43077
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

Q43077
AMO_PEA
Pisum sativum
Primary amine oxidase

PDB Structure

PDB 1W2Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Using Xenon as a Probe for Dioxygen-Binding Sites in Copper Amine Oxidases.
Duff, A.P., Trambaiolo, D.M., Cohen, A.E., Ellis, P.J., Juda, G.A., Shepard, E.M., Langley, D.B., Dooley, D.M., Freeman, H.C., Guss, J.M.
J.Mol.Biol.