CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family Histone deacetylase 8

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt Q9BY41
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

Q9BY41
HDAC8_HUMAN
Homo sapiens
Histone deacetylase 8

PDB Structure

PDB 1W22
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of a Eukaryotic Zn-Dependent Histone Deacetylase,Human Hdac8,Complexed with a Hydroxamic Acid Inhibitor
Vannini, A., Volpari, C., Filocamo, G., Caroli Casavola, E., Brunetti, M., Renzoni, D., Chakravarty, P., Paolini, C., De Francesco, R., Gallinari, P., Steinckuhler, C., Di Marco, S.
Proc.Natl.Acad.Sci.USA