CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt O92956
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt O92956
3.1.26.4
Ribonuclease H.
based on mapping to UniProt O92956
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt O92956

UniProtKB Entries (1)

O92956
POL_RSVSB
Rous sarcoma virus - Schmidt-Ruppin B
Gag-Pol polyprotein

PDB Structure

PDB 1VSM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integrase.
Lubkowski, J., Yang, F., Alexandratos, J., Merkel, G., Katz, R.A., Gravuer, K., Skalka, A.M., Wlodawer, A.
J.Biol.Chem.