CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family

Enzyme Information

2.7.7.49
RNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt O92956
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.4.23.-
Aspartic endopeptidases.
based on mapping to UniProt O92956
2.7.7.-
Nucleotidyltransferases.
based on mapping to UniProt O92956
3.1.26.4
Ribonuclease H.
based on mapping to UniProt O92956
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt O92956

UniProtKB Entries (1)

O92956
POL_RSVSB
Rous sarcoma virus - Schmidt-Ruppin B
Gag-Pol polyprotein

PDB Structure

PDB 1VSJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity.
Bujacz, G., Alexandratos, J., Wlodawer, A., Merkel, G., Andrake, M., Katz, R.A., Skalka, A.M.
J.Biol.Chem.