1 keywords

CATH Domain 1vr3A00

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.60 Sandwich
Topology 2.60.120 Jelly Rolls
Homologous Superfamily 2.60.120.10 Jelly Rolls

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

Enzyme Information

1.13.11.54
Acireductone dioxygenase (Fe(2+)-requiring).
based on mapping to UniProt Q99JT9
1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-(methylthio)-2- oxobutanoate + formate.
-!- If Ni(2+) is bound instead of Fe(2+), the reaction catalyzed by EC 1.13.11.53 occurs instead. -!- The enzyme from Klebsiella oxytoca (formerly Klebsiella pneumoniae) ATCC 8724 is involved in the methionine salvage pathway.

UniProtKB Entries (1)

Q99JT9
MTND_MOUSE
Mus musculus
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase

PDB Structure

PDB 1VR3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution.
Xu, Q., Schwarzenbacher, R., Krishna, S.S., McMullan, D., Agarwalla, S., Quijano, K., Abdubek, P., Ambing, E., Axelrod, H., Biorac, T., Canaves, J.M., Chiu, H.J., Elsliger, M.A., Grittini, C., Grzechnik, S.K., DiDonato, M., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Klock, H.E., Knuth, M.W., Koesema, E., Kreusch, A., Kuhn, P., Miller, M.D., Moy, K., Nigoghossian, E., Paulsen, J., Reyes, R., Rife, C., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., White, A., Wolf, G., Hodgson, K.O., Wooley, J., Deacon, A.M., Godzik, A., Lesley, S.A., Wilson, I.A.
Proteins