CATH Classification

Domain Context

CATH Clusters

Superfamily DNA helicase RuvA subunit, C-terminal domain
Functional Family

Enzyme Information

2.1.1.297
Peptide chain release factor N(5)-glutamine methyltransferase.
based on mapping to UniProt Q9WYV8
S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L- glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.
-!- Modifies the glutamine residue in the universally conserved glycylglycylglutamine (GGQ) motif of peptide chain release factor, resulting in almost complete loss of release activity. -!- Formerly EC 2.1.1.n16.

UniProtKB Entries (1)

Q9WYV8
PRMC_THEMA
Thermotoga maritima MSB8
Release factor glutamine methyltransferase

PDB Structure

PDB 1VQ1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of N5-glutamine methyltransferase, HemK(EC 2.1.1.-) (TM0488) from Thermotoga maritima at 2.80 A resolution
Joint Center for Structural Genomics (JCSG)
To be published