CATH Classification

Domain Context

CATH Clusters

Superfamily Aminomethyltransferase beta-barrel domains
Functional Family Aminomethyltransferase

Enzyme Information

2.1.2.10
Aminomethyltransferase.
based on mapping to UniProt P27248
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.

UniProtKB Entries (1)

P27248
GCST_ECOLI
Escherichia coli K-12
Aminomethyltransferase

PDB Structure

PDB 1VLO
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of aminomethyltransferase (T protein; tetrahydrofolate-dependent) of glycine cleavage system (np417381) from Escherichia coli k12 at 1.70 A resolution
Joint Center for Structural Genomics (JCSG)
To be published