1 keywords

CATH Domain 1vkmC00

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.40 3-Layer(aba) Sandwich
Topology 3.40.1790 Indigoidine synthase fold
Homologous Superfamily 3.40.1790.10 Indigoidine synthase domain

Domain Context

CATH Clusters

Superfamily Indigoidine synthase domain
Functional Family

Enzyme Information

4.2.1.70
Pseudouridylate synthase.
based on mapping to UniProt Q9X1H5
Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.
-!- The reaction it readily reversible. -!- While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.

UniProtKB Entries (1)

Q9X1H5
PSUG_THEMA
Thermotoga maritima MSB8
Pseudouridine-5'-phosphate glycosidase

PDB Structure

PDB 1VKM
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold.
Levin, I., Miller, M.D., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Biorac, T., Cambell, J., Canaves, J.M., Chiu, H.J., Deacon, A.M., DiDonato, M., Elsliger, M.A., Godzik, A., Grittini, C., Grzechnik, S.K., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Karlak, C., Klock, H.E., Koesema, E., Kreusch, A., Kuhn, P., Lesley, S.A., Morse, A., Moy, K., Nigoghossian, E., Ouyang, J., Page, R., Quijano, K., Reyes, R., Robb, A., Sims, E., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., Vincent, J., Wang, X., West, B., Wolf, G., Xu, Q., Zagnitko, O., Hodgson, K.O., Wooley, J., Wilson, I.A.
Proteins