CATH Domain 1vkmC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1790	Indigoidine synthase fold
	3.40.1790.10	Indigoidine synthase domain

Domain Context

CATH Clusters

Superfamily	Indigoidine synthase domain
Functional Family

Enzyme Information

4.2.1.70

Pseudouridylate synthase.

based on mapping to UniProt Q9X1H5

Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H(2)O.

-!- The reaction it readily reversible. -!- While the enzymes from Tetrahymena pyriformis and Agrobacterium tumefaciens produce pseudouridine 5'-phosphate the enzyme from Escherichia coli functions as a pseudouridine-5'-phosphate glycosidase in vivo.

UniProtKB Entries (1)

Q9X1H5

PSUG_THEMA

Thermotoga maritima MSB8

Pseudouridine-5'-phosphate glycosidase

PDB Structure

PDB	1VKM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. Levin, I., Miller, M.D., Schwarzenbacher, R., McMullan, D., Abdubek, P., Ambing, E., Biorac, T., Cambell, J., Canaves, J.M., Chiu, H.J., Deacon, A.M., DiDonato, M., Elsliger, M.A., Godzik, A., Grittini, C., Grzechnik, S.K., Hale, J., Hampton, E., Han, G.W., Haugen, J., Hornsby, M., Jaroszewski, L., Karlak, C., Klock, H.E., Koesema, E., Kreusch, A., Kuhn, P., Lesley, S.A., Morse, A., Moy, K., Nigoghossian, E., Ouyang, J., Page, R., Quijano, K., Reyes, R., Robb, A., Sims, E., Spraggon, G., Stevens, R.C., van den Bedem, H., Velasquez, J., Vincent, J., Wang, X., West, B., Wolf, G., Xu, Q., Zagnitko, O., Hodgson, K.O., Wooley, J., Wilson, I.A. Proteins