CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00735
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00735
THRB_BOVIN
Bos taurus
Prothrombin
P28507
HIR3A_HIRME
Hirudo medicinalis
Hirudin-3A

PDB Structure

PDB 1VIT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of a bovine thrombin-hirudin51-65 complex determined by a combination of molecular replacement and graphics. Incorporation of known structural information in molecular replacement.
Vitali, J., Martin, P.D., Malkowski, M.G., Olsen, C.M., Johnson, P.H., Edwards, B.F.
Acta Crystallogr.,Sect.D