CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1140 | Cyclic Phosphodiesterase; Chain: A, |
|
3.90.1140.10 | Cyclic phosphodiesterase |
Domain Context
CATH Clusters
| Superfamily | Cyclic phosphodiesterase |
| Functional Family | RNA 2',3'-cyclic phosphodiesterase |
Enzyme Information
| 3.1.4.58 |
RNA 2',3'-cyclic 3'-phosphodiesterase.
based on mapping to UniProt O57823
(Ribonucleotide)(n)-2',3'-cyclic phosphate + H(2)O = (ribonucleotide)(n)- 2'-phosphate.
-!- The enzyme hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. -!- In vitro the enzyme can also ligate tRNA molecules with 2',3'-cyclic phosphate to tRNA with 5'-hydroxyl termini, forming a 2'-5' phosphodiester linkage. -!- However, the ligase activity is unlikely to be relevant in vivo.
|
UniProtKB Entries (1)
| O57823 |
THPR_PYRHO
Pyrococcus horikoshii OT3
RNA 2',3'-cyclic phosphodiesterase
|
PDB Structure
| PDB | 1VGJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of Pyrococcus horikoshii 2'-5' RNA ligase at 1.94 A resolution reveals a possible open form with a wider active-site cleft
ACTA CRYSTALLOGR.,SECT.F
|