CATH Classification

Domain Context

CATH Clusters

Superfamily PAS domain
Functional Family Oxygen sensor protein DosP

Enzyme Information

3.1.4.52
Cyclic-guanylate-specific phosphodiesterase.
based on mapping to UniProt P76129
Cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine.
-!- Inhibited by Ca(2+) and Zn(2+). -!- Linearizes cyclic di-3',5'-guanylate, the product of EC 2.7.7.65 and an allosteric activator of EC 2.4.1.12 rendering it inactive. -!- It is the balance between these two enzymes that determines the cellular level of cyclic di-3',5'-guanylate.

UniProtKB Entries (1)

P76129
DOSP_ECOLI
Escherichia coli K-12
Oxygen sensor protein DosP

PDB Structure

PDB 1V9Y
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A redox-controlled molecular switch revealed by the crystal structure of a bacterial heme PAS sensor.
Kurokawa, H., Lee, D.S., Watanabe, M., Sagami, I., Mikami, B., Raman, C.S., Shimizu, T.
J.Biol.Chem.