CATH Classification

Domain Context

CATH Clusters

Superfamily Adenosylhomocysteinase-like
Functional Family Adenosylhomocysteinase

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P50250
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P50250
SAHH_PLAF7
Plasmodium falciparum 3D7
Adenosylhomocysteinase

PDB Structure

PDB 1V8B
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of S-Adenosyl-l-Homocysteine Hydrolase from the Human Malaria Parasite Plasmodium falciparum
Tanaka, N., Nakanishi, M., Kusakabe, Y., Shiraiwa, K., Yabe, S., Ito, Y., Kitade, Y., Nakamura, K.T.
J.Mol.Biol.