CATH Classification

Domain Context

CATH Clusters

Superfamily 6.10.140.800
Functional Family

Enzyme Information

6.3.2.2
Glutamate--cysteine ligase.
based on mapping to UniProt P0A6W9
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L- cysteine.
-!- Can use L-aminohexanoate in place of glutamate.

UniProtKB Entries (1)

P0A6W9
GSH1_ECOLI
Escherichia coli K-12
Glutamate--cysteine ligase

PDB Structure

PDB 1V4G
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
Hibi, T., Nii, H., Nakatsu, T., Kimura, A., Kato, H., Hiratake, J., Oda, J.
PROC.NATL.ACAD.SCI.USA