CATH Classification

Domain Context

CATH Clusters

Superfamily N-terminal domain of ligase-like
Functional Family

Enzyme Information

6.2.1.3
Long-chain-fatty-acid--CoA ligase.
based on mapping to UniProt Q5SKN9
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
-!- Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. -!- The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).

UniProtKB Entries (1)

Q5SKN9
LCFCS_THET8
Thermus thermophilus HB8
Long-chain-fatty-acid--CoA ligase

PDB Structure

PDB 1V26
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis of the Substrate-specific Two-step Catalysis of Long Chain Fatty Acyl-CoA Synthetase Dimer
Hisanaga, Y., Ago, H., Nakagawa, N., Hamada, K., Ida, K., Yamamoto, M., Hori, T., Arii, Y., Sugahara, M., Kuramitsu, S., Yokoyama, S., Miyano, M.
J.Biol.Chem.