CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12780 | N-terminal domain of ligase-like |
Domain Context
CATH Clusters
| Superfamily | N-terminal domain of ligase-like |
| Functional Family |
Enzyme Information
| 6.2.1.3 |
Long-chain-fatty-acid--CoA ligase.
based on mapping to UniProt Q5SKN9
ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
-!- Acts on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. -!- The liver enzyme acts on acids from C(6) to C(20); that from brain shows high activity up to C(24).
|
UniProtKB Entries (1)
| Q5SKN9 |
LCFCS_THET8
Thermus thermophilus HB8
Long-chain-fatty-acid--CoA ligase
|
PDB Structure
| PDB | 1V25 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural Basis of the Substrate-specific Two-step Catalysis of Long Chain Fatty Acyl-CoA Synthetase Dimer
J.Biol.Chem.
|